Lab Mission Statement:
The Wang Lab investigates the molecular logic underlying cell identity and plasticity, with a focus on the epigenetic, transcriptional, and RNA-based mechanisms that govern totipotency, pluripotency, germ cell development, and reprogramming. By dissecting how stem cell factors, histone variants, RNA modifications, and chromatin architecture interact with the translational machinery, we aim to uncover how stem cells acquire, maintain, and redefine their fates during early development and in response to stress or viral challenge. Through integrative approaches spanning proteomics, genomics, cell engineering, and disease modeling, our long-term goal is to translate fundamental insights into novel strategies for regenerative medicine, infertility treatment, and antiviral defense.
The Wang Lab investigates the molecular logic underlying cell identity and plasticity, with a focus on the epigenetic, transcriptional, and RNA-based mechanisms that govern totipotency, pluripotency, germ cell development, and reprogramming. By dissecting how stem cell factors, histone variants, RNA modifications, and chromatin architecture interact with the translational machinery, we aim to uncover how stem cells acquire, maintain, and redefine their fates during early development and in response to stress or viral challenge. Through integrative approaches spanning proteomics, genomics, cell engineering, and disease modeling, our long-term goal is to translate fundamental insights into novel strategies for regenerative medicine, infertility treatment, and antiviral defense.
Our ongoing research projects encompass the following four major areas:
Stem Cell and Developmental Potency
We study totipotent and pluripotent stem cells and their differentiation to understand zygotic genome activation and early development
We study totipotent and pluripotent stem cells and their differentiation to understand zygotic genome activation and early development
Somatic Cell Reprogramming and iPSCs
We study the molecular mechanisms of iPSC reprogramming and their applications
We study the molecular mechanisms of iPSC reprogramming and their applications
Adult Stem Cells and Human Diseases
We study and apply multiple adult stem cell models (e.g., HSCs, NSCs, SSCs) to understand human diseases, including cancers, sleep deprivation, male infertility
We study and apply multiple adult stem cell models (e.g., HSCs, NSCs, SSCs) to understand human diseases, including cancers, sleep deprivation, male infertility
Stem Cell Antiviral Immunity
We study the intrinsic antiviral immunity of pluripotent stem cells
We study the intrinsic antiviral immunity of pluripotent stem cells
